AntiAging Reports

Current revision June 23, 2015.

AntiAging Reports researches the scientific, technical, medical and economic literature for promising anti-aging treatments.
    At present there seem to be no treatments that promise to completely eliminate or block the effects of aging. However there are a number of treatments for which there is evidence of being likely to overcome many of the features of aging, some of them quite significant, and our researches address those.
    Individual research reports record, detail and weigh the evidence for specific treatments and, where possible, offer information on how to obtain and use the treatment. As our research continues and potential new treatments emerge, the information and evidence will be posted and existing reports will be updated as new information becomes available. Our reports are works in progress, as is the scientific research on which they report. Please accept that they are not polished white papers but rather records of studies under way and continuously evolving. During the term of your subscription, you will be notified by email of any significant changes or developments on any of the treatments we are investigating.
    A series of treatments that promise to extend a healthy, functional life indefinitely are beginning to emerge.

Below is a list of topics on which reports are underway.

Alk5i: Researchers at Stanford appear to be on the track of a mechanism which would restore the ability of at least aged muscle tissue to regenerate as effectively as young tissue, and researchers at UC Berkeley this year published results that seem to identify a drug that restores the regenerative capacity of the hippocampus and muscle tissue: "Confirming these conclusions and demonstrating clear therapeutic significance, systemic administration of an Alk5 Type I receptor kinase inhibitor simultaneously improved repair of skeletal muscle and enhanced hippocampal neurogenesis in 2-year old mice, suggesting promising strategies for combating multiple age-related degenerative disorders, which are known to contribute to the loss of a person’s agility, mobility, memory, learning, and independence." Stay tuned while we research the likelihood of the effectiveness and the availability of this mechanism.

SIRT-1: University of Singapore and National University of Singapore researchers have published research indicating this substance may be useful in countering age-related declines in the functioning of histones, transcription factors, and other molecules that collectively modulate energy metabolism, stress response, and cell/tissue survival, including neuronal survival and protection from cellular senescence and stress in the neural, cardiovascular, and renal systems.

GDF11: Sounds good, made a big splash recently, material is obtainable, but now some significant pullback. My investigation is underway.

Elastin

Sarcopoenia: Decline of muscle strength is one of the major age-related debits. Steroids such as Human Growth Hormone and Testosterone ameliorate some of the symptoms but have unsatisfactory side effects and do not resolve the fundamental problem. Researchers at Columbia University believe they may have elucidated the mechanism of age-related sarcopenia and identified a substance, called S107, that would counter it, and in fact a drug that seems to work along these lines is in Phase II clinical trials for heart failure. Our report examines the state of the research, estimates the likelihood of the treatments' effectiveness, and discusses possible avenues to obtaining treatment.

AGEs: Advanced Glycosylation End Products accumulate in cells in clumps over time. At least two treatments have been tested.

Mitochondria: Errors in copied mitochondrial DNA accumulate. Clearance of erroneous mitochondria declines substantially with age. Inadequate mitochondrial autophagy, or mitophagy, may be a successful point of attack. Interestingly, a commonly available antioxidant appears to have a significant protective effect on both lung and brain cell mitochondria. Alone or combined with autophagy of senescent cells, removal of defective and inactive mitochondria could create a significant degree of rejeuvenation.

17β estradiol (E2)

Senescent cells: Cells that have become disfunctional but do not self-destruct accumulate with age. This can be described as an age-related decline in the processes of autophagy. Strategies for their removal could create a significant degree of rejeuvenation.

Metformin

Stem cells: Ultimately, stem cell therapy may prove to be an essential anti-aging treatment, and already can be used to replace certain defective organs. At present, replacement bladders and tracheas are proven technologies, and preliminary results for heart tissue replacement seem solid. Researchers at Tokyo University of Science have regenerated fully functional, growing, integrated human hair follicles from adult epithelial stem cells and dermal papilla cells, an advancement that has promise for presbycusis.

Resveratrol: probably ineffective.

Rapamycin: hints of immortality.

Brain: AL721; Brain-Derived Neurotropic Factor

Alzheimers: Two seemingly effective treatments exist, and although testing in humans has been very limited, an individual's circumstances might impel them to assume significant risk. This report discusses the evidence and identifies the researchers involved.

Nutrition: lycopene

● Autophagy [Spermidine]

Miscellaneous: Eliminating or reducing erroneous chromsome counts, per the Mayo Clinic.
    Queen Mary, University of London, researchers have identified an age-related decline in levels of a protein that protects gums and jaw bone from erosion, offering a possible treatment to stop age-related periodontitis.    

Revved-Up Protein Fights Aging. [BuBR1]

Antioxidants: A number of antioxidants have each been shown to increase lifespan 4-8% in animal models, although others seem not to. There have been suggestions that more than one antioxidant must be taken.

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